Regulation of glycogen synthesis in rat skeletal muscle after glycogen-depleting contractile activity: effects of adrenaline on glycogen synthesis and activation of glycogen synthase and glycogen phosphorylase
نویسندگان
چکیده
منابع مشابه
Allosteric regulation of glycogen synthase controls glycogen synthesis in muscle.
Glycogen synthase (GS), a key enzyme in glycogen synthesis, is activated by the allosteric stimulator glucose-6-phosphate (G6P) and by dephosphorylation through inactivation of GS kinase-3 with insulin. The relative importance of these two regulatory mechanisms in controlling GS is not established, mainly due to the complex interplay between multiple phosphorylation sites and allosteric effecto...
متن کاملControl of glycogen synthesis is shared between glucose transport and glycogen synthase in skeletal muscle fibers.
The effects of transgenic overexpression of glycogen synthase in different types of fast-twitch muscle fibers were investigated in individual fibers from the anterior tibialis muscle. Glycogen synthase was severalfold higher in all transgenic fibers, although the extent of overexpression was twofold greater in type IIB fibers. Effects of the transgene on increasing glycogen and phosphorylase an...
متن کاملIn vivo regulation of muscle glycogen synthase and the control of glycogen synthesis.
The activity of glycogen synthase (GSase; EC 2.4.1.11) is regulated by covalent phosphorylation. Because of this regulation, GSase has generally been considered to control the rate of glycogen synthesis. This hypothesis is examined in light of recent in vivo NMR experiments on rat and human muscle and is found to be quantitatively inconsistent with the data under conditions of glycogen synthesi...
متن کاملGlycogen Synthetase Activity in Skeletal Muscle. Interconversion of Two Forms and Control of Glycogen Synthesis.
Glycogen synthetase (uridine diphosphate glucose-glycogen glucosyltransferase, EC 2.4.1.11) has been extensively studied in liver and in skeletal muscle (3-8). In extracts from a variety of tissues, measurements of the activity of the enzymes catalyzing the steps from n-glucose 6-phosphate to glycogen suggested that glycogen synthetase was rate-limiting and, hence, was likely to be important in...
متن کاملEffects of endotoxin on gluconeogenesis, glycogen synthesis, and liver glycogen synthase in mice.
This study was undertaken to characterize the nature of carbohydrate loss due to endotoxin poisoning in mice and to elucidate mechanisms responsible for the changes. Female ICR mice, fasted overnight, were injected intraperitoneally with a mean lethal dose of endotoxin extracted from Salmonella typhimurium strain SR-11. Liver glycogen levels, alanine-U-(14)C and pyruvate-2-(14)C incorporation i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1999
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj3440231